منابع مشابه
Elastin degradation: an effective biomarker in COPD.
Chronic obstructive pulmonary disease (COPD) is well recognized as one of the major health problems in the world (1,2). In the United States, it has moved up to the third leading cause of death (3). Th e disease has been defi ned as progressive and not fully reversible (2). Existing therapies off er benefi ts. Th erapies to reverse its progressive course have had limited success. Th ere is clea...
متن کاملCrosslinked alpha-elastin biomaterials: towards a processable elastin mimetic scaffold.
Elastin is a critical biochemical and biomechanical component of vascular tissue. However, elastin is also highly insoluble and therefore difficult to process into new biomaterials. We present a simple approach for synthesizing elastin-based materials from two commercially available and water-soluble components: alpha-elastin and a diepoxy crosslinker. Reaction pH was shown to modulate the degr...
متن کاملDesign of an elastin-layered dermal regeneration template☆
We demonstrate a novel approach for the production of tunable quantities of elastic fibers. We also show that exogenous tropoelastin is rate-limiting for elastin synthesis regardless of the age of the dermal fibroblast donor. Additionally, we provide a strategy to further enhance synthesis by older cells through the application of conditioned media. We show that this approach delivers an elasti...
متن کاملAn alternative structure model for the polypentapeptide in elastin.
Polypentapeptides (GVGVP)n which are designed in analogy to the connective tissue protein elastin are reported to transform various kinds of energy into mechanical work by the so-called deltaT(t)-mechanism in cross-linked macroscopic polypentapeptide (PPP) films. In the literature, the responsible element of conformation in such polypeptides is described as a beta-spiral and the deltaT(t) effec...
متن کاملElastin stabilizes an infarct and preserves ventricular function.
BACKGROUND After a myocardial infarction, the injured region becomes fibrotic and the myocardial scar may expand if the ventricular wall lacks elasticity. Cardiac dilatation may precipitate the vicious cycle of progressive heart failure. The present study evaluated the functional benefits of increasing elastin within a myocardial scar using cell based gene therapy. METHODS AND RESULTS A myoca...
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ژورنال
عنوان ژورنال: Nature
سال: 1960
ISSN: 0028-0836,1476-4687
DOI: 10.1038/185320a0